SCCM Resource Library-Putting Basic Science to Work: How State-of-the-Art Scientific Technology Can Inform Critical Care

Video Transcription

Video Summary

The video discusses the strengths and weaknesses of animal models in understanding human critical illness. Animal models are useful in studying disease biology and developing treatments, but their accuracy in mimicking human diseases is questioned. Researchers should improve animal models by considering factors such as gene expression, age, and strain differences. The speaker also recommends implementing co-clinical trials to align animal studies with human clinical practice.<br /><br />The video also focuses on immunomodulation in sepsis, where the body's immune response to infection often causes illness. Numerous clinical trials targeting cytokines and coagulation cascades have not shown significant improvements in patient outcomes. Trials exploring immunostimulatory therapies, such as low-dose corticosteroids and IL-7, have shown promise. However, patient heterogeneity poses a challenge in conducting clinical trials for sepsis, as factors like patient selection and timing of intervention can influence treatment effectiveness. Despite the challenges, researchers are striving to find better therapeutic strategies for sepsis patients.

Asset Subtitle

Immunology, Research, 2020

Asset Caption

The Society of Critical Care Medicine's Critical Care Congress features internationally renowned faculty and content sessions highlighting the most up-to-date, evidence-based developments in critical care medicine. This is a presentation from the 2020 Critical Care Congress held February 16-19, 2020, in Orlando, Florida, USA.

Learning Objectives

Review bench techniques in clinical research, including relevance in study design as a primary readout for clinical outcome variables
Analyze strengths and weaknesses and demystify commonly used state-of-the-art basic science technologies
Discuss how state-of-the-art technology driving discovery in basic scientific research is applicable to critical care
Appraise basic scientific discoveries that can translate to clinical trials and to the bedside in critical care

Integrating Translational Genomics Into Clinical Medicine

Hector R. Wong

Mitochondrial Origin of Multiorgan System Disease

Richard Levy

Building Better Models

Kenneth E. Remy

Next-Generation Diagnostics With CRISPR

Daniel Chertow

Immunomodulation in Translational Science

Balasubramanian Venkatesh

Meta Tag

Content Type Presentation

Knowledge Area Immunology

Knowledge Area Research

Knowledge Level Foundational

Knowledge Level Intermediate

Knowledge Level Advanced

Membership Level Select

Membership Level Professional

Membership Level Associate

Tag Genetics

Tag Infectious Diseases

Year 2020

Keywords

animal models

strengths

weaknesses

human critical illness

disease biology

treatments

accuracy

gene expression

age

strain differences

co-clinical trials

immunomodulation

sepsis

clinical trials

patient outcomes

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