SCCM Resource Library-REDISCOVER-ICU: Utilizing Data to Study Drug Repurposing Beyond COVID-19

Pdf Summary

The COVID-19 pandemic highlighted significant challenges in the healthcare system, including inequities and limited treatment options for ICU patients. In response, the Society of Critical Care Medicine's (SCCM) Discovery, the Critical Care Research Network, established the VIRUS registry to address these issues, focusing on improved data collection methods for clinical studies. This initiative revealed the necessity for novel, efficient data gathering techniques from electronic health records (EHRs) to reduce resource burdens.<br /><br />Collaborating with the Critical Path Institute's CURE Drug Repurposing Collaboratory (CDRC), SCCM worked on the CURE ID project, which aims to crowdsource global medical community experiences with repurposing drugs to treat COVID-19. This partnership extends into other critical conditions through the REDISCOVER-ICU study. REDISCOVER-ICU aspires to utilize real-world data analysis to repurpose existing drugs for illnesses like sepsis and acute kidney injury. <br /><br />This effort aims to build a comprehensive network that facilitates near-real-time data collection, aiding clinicians in patient care and enabling fast-paced research. REDISCOVER-ICU is designed to address gaps in past research projects, ensuring diverse representation, including ethnic minorities and socioeconomically disadvantaged populations. As highlighted by investigators, the study focuses on rapid, automated data collection to expedite the evaluation of treatments, replacing slow traditional methods with efficient, informed decision-making processes.<br /><br />The study will initially focus on long COVID and sepsis, with SCCM leading data analysis and facilitating access to both participating and, eventually, non-participating sites. REDISCOVER-ICU also explores future AI research opportunities to manage extensive data. Overall, this initiative aims to bridge healthcare gaps and expedite the translation of research into practical patient care, fitting the needs of modern medical science.

Asset Subtitle

Research, 2023, 0:05:14

Asset Caption

"This article was first published in the Summer 2023 issue of Critical Connections.

The COVID-19 pandemic exposed significant gaps in the healthcare system, such as healthcare inequit ies and the need for more treatment options for intensive care unit patients with serious illnesses. Looking beyond COVID-19 to sepsis and other critical care illnesses, the Society of Critical Care Medicine and Critical Path Institute’s CURE Drug Repurposing Collaboratory are collaborating on the new study Repurposing Drugs in Intensive Care Units Through
Real-World Data Analysis (REDISCOVER-ICU).

Critical Connections, the critical care industry’s only newsmagazine, provides information on cutting-edge topics in critical care useful to the entire multiprofessional team."

Meta Tag

Content Type Article

Knowledge Area Research

Knowledge Area Pharmacology

Membership Level Associate

Membership Level Professional

Membership Level Select

Tag Outcomes Research

Tag Education

Year 2023

Keywords

COVID-19

healthcare inequities

ICU treatment

VIRUS registry

data collection

CURE ID project

drug repurposing

REDISCOVER-ICU

real-world data

AI research

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