SCCM Resource Library-Restrictive Versus Liberal Fluid Management for Sepsis-Induced Hypotension (NEJM)

Restrictive Versus Liberal Fluid Management for Sepsis-Induced Hypotension (NEJM)

Video Transcription

Video Summary

The Crystalloid Liberal or Vasopressors early resuscitation study in sepsis (CLOVAS) was conducted to determine the best approach for fluid resuscitation in septic shock. The study compared a more restrictive approach, prioritizing vasopressors and preventing fluid accumulation, with a more liberal approach, focusing on fluid loading to improve organ function. The study involved 1,563 patients and found no significant difference in 90-day mortality between the two approaches. Secondary outcomes such as organ failure, ARDS onset, and serious adverse events also showed no significant differences. The study suggests that neither approach is superior and future research should explore other treatment options for sepsis.

Asset Subtitle

Sepsis, 2023

Asset Caption

Type: plenary | Plenary: Late Breaking Studies That Will Change Your Practice (SessionID 9000002)

Meta Tag

Content Type Presentation

Knowledge Area Sepsis

Membership Level Professional

Membership Level Select

Tag Fluids Resuscitation Management

Year 2023

Keywords

Crystalloid Liberal

Vasopressors early resuscitation

sepsis

fluid resuscitation

septic shock

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