SCCM Resource Library-Resuscitation With Vitamin C, Hydrocortisone, and Thiamine in Children With Septic Shock: A Multicenter, Randomized Pilot Study and the Corresponding Observational Study of Serum Levels of Vitamin C and Thiamine in Children With Suspected Sepsis: A Prospective Observational Cohort Study (PCCM)

Resuscitation With Vitamin C, Hydrocortisone, and Thiamine in Children With Septic Shock: A Multicenter, Randomized Pilot Study and the Corresponding Observational Study of Serum Levels of Vitamin C and Thiamine in Children With Suspected Sepsis: A Prospective Observational Cohort Study (PCCM)

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Video Summary

The pilot trial presented focused on the ENZYGES Pediatric Study Group's investigation into metabolic interventions for children with septic shock. Key areas included using early inotropes and a combination of vitamin C, thiamine, and hydrocortisone. Results highlighted a correlation between low vitamin C levels and increased organ dysfunction. The pilot study demonstrated feasibility and strong parental interest, despite open-label design and steroid use in standard care. The trial did not record major drug-related side effects and emphasized quick intervention delivery. Although not powered for clinical outcomes, early signs suggested faster shock reversal in the intervention group. Lessons learned include the necessity of pragmatic trial designs and improved follow-up strategies. A subsequent three-arm trial is underway, investigating hydrocortisone alone, with results expected in two years. The study underscores a significant interest in refining adjunctive strategies to improve outcomes for pediatric septic shock.

Asset Caption

One-Hour Concurrent Session | Late-Breaking Studies Affecting Patient Outcomes II

Meta Tag

Content Type Presentation

Membership Level Professional

Membership Level Select

Year 2024

Keywords

pediatric septic shock

metabolic interventions

vitamin C

early inotropes

hydrocortisone

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