SCCM Resource Library-Role of Biomarkers in Detection of Infection and Sepsis

Video Transcription

Video Summary

The speaker discusses the role of biomarkers, specifically procalcitonin, in the detection and management of infection in sepsis. They highlight the high use of antibiotics in ICU patients, but note that there is still no gold standard diagnostic for sepsis. The speaker describes the potential of biomarkers like procalcitonin to inform clinical judgment and improve patient outcomes. They discuss the characteristics of procalcitonin and its performance in discriminating bacterial infection. The speaker also explores the use of procalcitonin in starting and stopping antibiotics in respiratory tract infections and critical illness. They present evidence from studies and guidelines, emphasizing the need for more research on the real-world utility of procalcitonin, the integration of biomarkers into antibiotic stewardship programs, the rapid diagnosis of pathogens, and the use of procalcitonin in the context of COVID-19. The speaker concludes by stating that while procalcitonin has limited utility in antibiotic initiation and escalation, it does not appear to be harmful in guiding antibiotic discontinuation in critical illness and sepsis. Future research is needed to understand how providers respond to procalcitonin results and to determine the generalizability of its benefits in different global regions.

Asset Subtitle

Sepsis, 2022

Asset Caption

Identification of infection can sometimes be challenging. The session will cover ew modalities in the diagnosis of infection and sepsis, including FDG-PET/CT, biomarkers, and PCR-based diagnostics.

Meta Tag

Content Type Presentation

Knowledge Area Sepsis

Knowledge Level Advanced

Learning Pathway Sepsis Resources

Membership Level Select

Tag Infection

Year 2022

Keywords

biomarkers

procalcitonin

sepsis

antibiotics

infection

critical illness

Presentation

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2022

Advanced

Sepsis Resources

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