SCCM Resource Library-Scleroderma Renal Crisis

Video Transcription

Video Summary

In this video, Dr. Eleanor Valenzi discusses scleroderma renal crisis, which is a life-threatening complication of systemic sclerosis. Systemic sclerosis is an autoimmune disorder that results in fibrosis of various organs, including the skin, lungs, and kidneys. Scleroderma renal crisis is characterized by abrupt onset of severe hypertension, acute kidney injury, and a bland urine sediment. Treatment of scleroderma renal crisis involves rapid blood pressure control, primarily with angiotensin-converting enzyme (ACE) inhibitors. ACE inhibitors have been shown to improve kidney function and survival in these patients. Other manifestations of scleroderma renal crisis may include microangiopathic hemolytic anemia and thrombocytopenia. Early recognition of scleroderma renal crisis is important for initiating treatment promptly. While renal crisis used to be the leading cause of death in scleroderma, the development of ACE inhibitor treatment has significantly improved outcomes.

Asset Subtitle

Renal, Immunology, 2022

Asset Caption

Primary immunologic disorders are infrequent but devastating causes of morbidity and mortality in the ICU. The rapidity with which these conditions can progress requires equally swift recognition and intervention. These rare conditions can go unrecognized, leading to increased harm to patients. This session's expert panel will discuss key features of three uncommon but important immunologic disorders for the critical care clinician, with a goal of ensuring quick initiation of needed therapy.

Meta Tag

Content Type Presentation

Knowledge Area Renal

Knowledge Area Immunology

Knowledge Level Intermediate

Knowledge Level Advanced

Membership Level Select

Tag Renal

Tag Immunology

Year 2022

Keywords

scleroderma renal crisis

systemic sclerosis

autoimmune disorder

hypertension

angiotensin-converting enzyme inhibitors

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