SCCM Resource Library-September Journal Club: Spotlight on Pharmacy (2022)

Video Transcription

Video Summary

In this Journal Club Spotlight on Pharmacy webcast, three presenters discussed different articles. The first presenter discussed a study on the association of vancomycin plus piperacillin/tazobactam with changes in creatinine versus cystatin C in critically ill adults. The study found that the combination of vancomycin plus piperacillin/tazobactam increased acute kidney injury risk but did not affect other kidney function biomarkers or clinical outcomes such as mortality and need for dialysis. The presenter concluded that the rise in creatinine levels may not necessarily indicate nephrotoxicity and that the combination can be used in specific situations. The second presenter discussed a study on the use of andaxanet alpha versus four-factor prothrombin complex concentrate for the reversal of apixaban or rivaroxaban-associated intracranial hemorrhage. The study found that andaxanet alpha was associated with better hemostatic effectiveness and a reduction in all-cause mortality at 30 days compared to four-factor prothrombin complex concentrate. The presenter recommended the use of andaxanet alpha over four-factor prothrombin complex concentrate for the management of factor 10a-associated intracranial hemorrhage. The third presenter discussed a study on the combination of tranexamic acid and blood transfusions in patients at risk for hemorrhage. The study found that the combination of tranexamic acid and packed red blood cell transfusions was associated with decreased mortality at 30 days compared to tranexamic acid alone or packed red blood cell transfusions alone. The presenter concluded that it was reasonable to incorporate the use of both tranexamic acid and packed red blood cell transfusions for pre-hospital resuscitation of trauma patients. Overall, the studies highlighted the importance of individualizing treatment based on patient characteristics and clinical judgment. The presenters acknowledged the limitations of the studies and the need for further research.

Asset Subtitle

Pharmacology, Neuroscience, Trauma, 2022

Asset Caption

"The Journal Club: Spotlight on Pharmacy webcast series focuses on pharmacy topics. This event is held on the third Friday of each month and features lively discussion and in-depth presentations on the latest research.

Dimitar Zelenkov, PharmD (Twitter handle: @zelenkov_rx)
Miano TA, Hennessy S, Yang W, et al. Association of vancomycin plus piperacillin-tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study. Intensive Care Med. 2022 Jul 14. doi: 10.1007/s00134-022-06811-0. Online ahead of print.

Savannah Gross, PharmD
Costa OS, Connolly SJ, Sharma M, et al. Andexanet alfa versus four-factor prothrombin complex concentrate for the reversal of apixaban- or rivaroxaban-associated intracranial hemorrhage: a propensity score-overlap weighted analysis. Crit Care. 2022 Jun 16;26(1):180.

Brittany Curran, PharmD
Deeb AP, Hoteit L, Li S, et al. Prehospital synergy: tranexamic acid and blood transfusion in patients at high risk for hemorrhage. J Trauma Acute Care Surg. 2022 Jul 1;93(1):52-58.

Follow the conversation at #SCCMCPPJC."

Meta Tag

Content Type Webcast

Knowledge Area Pharmacology

Knowledge Area Neuroscience

Knowledge Area Trauma

Knowledge Level Intermediate

Knowledge Level Advanced

Membership Level Select

Membership Level Professional

Tag Antibiotics

Tag Cerebral Blood Flow

Tag Hemorrhage

Year 2022

Keywords

Journal Club Spotlight on Pharmacy

vancomycin plus piperacillin/tazobactam

creatinine

cystatin C

acute kidney injury

andaxanet alpha

intracranial hemorrhage

tranexamic acid

blood transfusions

resuscitation

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