SCCM Resource Library-Sirtuins and Immunometabolism in Sepsis

Video Transcription

Video Summary

In this presentation, Vidula Vacharyani discusses the role of sirtuins and immunometabolism in sepsis. Sepsis is a life-threatening condition that results from an overactive immune response to an infection. Studies have shown that patients who die from sepsis often have immunosuppression and opportunistic infections. Vacharyani's research focuses on the shift from hyper-inflammation to hypo-inflammation in sepsis and the role of sirtuins in this process. Sirtuins are enzymes that regulate cellular metabolism and inflammation. Vacharyani's lab has found that sirtuins, specifically SIRT1 and SIRT2, play a role in both hyper- and hypo-inflammation during sepsis. Targeting sirtuins may have potential therapeutic benefits in sepsis treatment.

Asset Subtitle

Sepsis, Immunology, 2023

Asset Caption

Type: one-hour concurrent | Metabolic Drivers of Sepsis: Roadside Diners (SessionID 1201356)

Meta Tag

Content Type Presentation

Knowledge Area Sepsis

Knowledge Area Immunology

Membership Level Professional

Membership Level Select

Tag Sepsis

Tag Immunology

Year 2023

Keywords

sirtuins

immunometabolism

sepsis

hyper-inflammation

hypo-inflammation

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