SCCM Resource Library-Sooner or Later: When Should We Start to Add Vasopressors?

Sooner or Later: When Should We Start to Add Vasopressors?

Video Transcription

Video Summary

Dr. Eithan Pelton, a prominent figure in acute care research, discussed optimal timing and methods for administering vasopressors in septic shock. Highlighting thresholds over time-based criteria, he referenced key studies like the sepsis PAM trial and the 65 trial, which investigated blood pressure targets in septic patients, showing no significant difference in mortality outcomes. He also addressed fluid resuscitation strategies through the Clover’s trial, advocating for prompt vasopressor use without central venous access delays. On vasopressin, he presented past influential studies like the VAST and VANISH trials, noting vasopressin’s potential benefits as a secondary treatment in septic shock. Despite its high cost and variable practice patterns, vasopressin remains critical, with Dr. Pelton emphasizing the need for more precise data, as seen in the upcoming VASPR trial aimed at refining treatment thresholds in septic shock.

Asset Caption

One-Hour Concurrent Session | Rethinking Vasopressors: Evolving Evidence and Emerging Concepts in Vasopressor Administration

Meta Tag

Content Type Presentation

Membership Level Professional

Membership Level Select

Year 2024

Keywords

septic shock

vasopressors

vasopressin

fluid resuscitation

clinical trials

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