SCCM Resource Library-Spikes, Sharps, and Drug-Drug interactions: Understanding EEG in the General Critical Care Population (Part 1)

Spikes, Sharps, and Drug-Drug interactions: Understanding EEG in the General Critical Care Population (Part 1)

Video Transcription

Video Summary

The speaker discussed the treatment options for status epilepticus during the third and fourth phases of management, as well as the role of drug interactions in treatment. While there is limited data for these phases, the use of benzodiazepines and various antiseizure medications (ASMs) are commonly employed. Midazolam, propofol, and ketamine are the main anesthetic drugs considered during the third phase. Midazolam is a hemodynamically neutral agent that primarily targets GABA receptors, while propofol provides GABA activity and a slight anti-NMDA effect. Ketamine, an anti-NMDA agent, is viewed favorably due to its hemodynamic neutrality. When it comes to drug interactions, phenytoin and DOACs, as well as valproic acid and carbapenems, should be avoided due to significant interactions. The speaker also mentioned the ketogenic diet as a non-pharmacological option for patients who do not respond to medication treatments. Overall, the choice of treatment and drug combinations in status epilepticus are patient-specific and require careful consideration of pharmacokinetic and pharmacodynamic interactions.

Asset Subtitle

Neuroscience, Procedures, 2023

Asset Caption

Type: two-hour concurrent | Time Is Brain: An Update on Management and Pharmacology Strategies for Acute Neurologic Emergencies (SessionID 1202433)

Meta Tag

Content Type Presentation

Knowledge Area Neuroscience

Knowledge Area Procedures

Membership Level Professional

Membership Level Select

Tag electroencephalogram EEG

Year 2023

Keywords

status epilepticus

treatment options

drug interactions

benzodiazepines

antiseizure medications

ketogenic diet

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