SCCM Resource Library-Star Research Presentations: Sepsis Therapies

Video Transcription

Video Summary

In this video, three different studies related to septic shock are presented. The first study focuses on the impact of delays in second-dose beta-lactam antibiotics on mortality in sepsis and septic shock. The study found that delays in second-dose antibiotics were associated with increased risk of in-hospital mortality and mechanical ventilation. Risk factors for delays included more frequent dosing intervals, boarding in the emergency department, and older age. The second study evaluates the impact of different doses of vasopressin on hemodynamic response in septic shock patients. The study found that there was no significant difference in the incidence of hemodynamic response between patients receiving a dose of 0.03 units per minute and those receiving a dose of 0.04 units per minute. The third study investigates the timing of hydrocortisone initiation in septic shock patients. The study found that early initiation of hydrocortisone, within the first 12 hours after shock onset, was associated with shorter vasopressor duration and lower ICU mortality. However, further prospective data are warranted to confirm these findings. Overall, these studies provide insights into the importance of timely administration of antibiotics and other therapies in septic shock and the potential impact on patient outcomes.

Asset Subtitle

Sepsis, 2020

Asset Caption

The Society of Critical Care Medicine's Critical Care Congress features internationally renowned faculty and content sessions highlighting the most up-to-date, evidence-based developments in critical care medicine. This is a presentation from the 2020 Critical Care Congress held February 16-19, 2020, in Orlando, Florida, USA.

29-Impact of Delays in Second-Dose Beta-Lactam Antibiotics on Mortality in Sepsis and Septic Shock

John Hammer

30-Improving Time to Urgent Antibiotic Administration in Critically Ill Patients With Suspected Sepsis

Brian J. Anderson

31-Hemodynamic Response to Initial Vasopressin Dose of 0.03 Versus 0.04 Units/Min in Septic Shock

Seth R. Bauer

32-Evaluation of the Initiation Timing of Stress-Dose Steroids in Adult Patients With Septic Shock

Gretchen L. Sacha

Meta Tag

Content Type Presentation

Knowledge Area Sepsis

Knowledge Level Advanced

Learning Pathway Sepsis Resources

Membership Level Select

Membership Level Professional

Membership Level Associate

Tag Antibiotics

Tag Shock

Tag Vasoactive Agents

Year 2020

Keywords

septic shock

delays in second-dose antibiotics

mortality

mechanical ventilation

risk factors

vasopressin

hemodynamic response

hydrocortisone initiation

ICU mortality

Sepsis

Antibiotics

Shock

Vasoactive Agents

Presentation

Select

Professional

Associate

2020

Advanced

Sepsis Resources

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