SCCM Resource Library-Stress Ulcer Prophylaxis Versus Placebo: A Blinded Randomized Controlled Pilot Trial to Evaluate the Safety of Two Strategies in Critically Ill Infants With Congenital Heart Disease (SUPPRESS-CHD) (PCCM)

Stress Ulcer Prophylaxis Versus Placebo: A Blinded Randomized Controlled Pilot Trial to Evaluate the Safety of Two Strategies in Critically Ill Infants With Congenital Heart Disease (SUPPRESS-CHD) (PCCM)

Back to course

Video Transcription

Video Summary

In this presentation, the speaker discusses a study on stress ulcer prophylaxis in infants with congenital heart disease in the pediatric cardiac ICU. Stress ulcer prophylaxis aims to prevent upper gastrointestinal (GI) bleeds, which are complications of critical illnesses. However, recent observations suggest that these prophylactic measures might lead to adverse outcomes such as hospital-acquired infections. The study, published in Pediatric Critical Care Medicine, was sponsored by multiple institutions and assessed the feasibility and safety of withholding stress ulcer prophylaxis. It involved a randomized, double-blind, placebo-controlled trial with infants under 12 months of age. The study successfully screened 1,426 patients and randomized 68, finding no cases of clinically significant upper GI bleeds in the trial. The next steps include a larger, multicenter trial to further explore the implications and validate these findings. The research also pushes for re-evaluation of the current practice due to potential risks associated with stress ulcer prophylaxis.

Asset Caption

One-Hour Concurrent Session | Late-Breaking Studies Affecting Patient Outcomes I

Meta Tag

Content Type Presentation

Membership Level Professional

Membership Level Select

Year 2024

Keywords

stress ulcer prophylaxis

congenital heart disease

pediatric cardiac ICU

randomized controlled trial

hospital-acquired infections

	Society of Critical Care Medicine 500 Midway Drive Mount Prospect, IL 60056 USA Phone: +1 847 827-6888 Fax: +1 847 439-7226 Email: support@sccm.org	Contact Us About SCCM Newsroom Advertising & Sponsorship DONATE	MySCCM LearnICU Patients & Families Surviving Sepsis Campaign Critical Care Societies Collaborative	GET OUR NEWSLETTER
© Society of Critical Care Medicine. All rights reserved. \| Privacy Statement \| Terms & Conditions The Society of Critical Care Medicine, SCCM, and Critical Care Congress are registered trademarks of the Society of Critical Care Medicine.