SCCM Resource Library-Subphenotypes in ARDS: Is It Time for Personalized Medicine, Including for COVID-19 Patients?

Subphenotypes in ARDS: Is It Time for Personalized Medicine, Including for COVID-19 Patients?

Video Transcription

Video Summary

In this talk, Dr. Kathleen Liu discusses the concept of subphenotypes in acute respiratory distress syndrome (ARDS) and whether personalized medicine, including for COVID-19 patients, is necessary. She explains that phenotyping refers to categorizing patients into subgroups based on specific characteristics or features. Different ways to phenotype ARDS have been discussed for decades, including risk factors, severity, radiographic patterns, and COVID-19 versus typical ARDS. The goal of phenotyping is to find groups of patients that respond differently to therapies in order to improve outcomes. Dr. Liu describes the challenges and variability in using clinically obvious phenotypes and explores the potential of identifying hidden or latent phenotypes using biomarkers and machine learning approaches. She presents research findings on the hyperinflammatory phenotype and its association with worse outcomes in ARDS and COVID-19 ARDS patients. However, she emphasizes the need for prospective validation and clinical testing before implementing personalized medicine strategies for ARDS.

Asset Subtitle

Pulmonary, 2023

Asset Caption

Type: one-hour concurrent | ARDS in the Time of COVID-19 (SessionID 1198064)

Meta Tag

Content Type Presentation

Knowledge Area Pulmonary

Membership Level Professional

Membership Level Select

Tag Acute Respiratory Distress Syndrome ARDS

Year 2023

Keywords

subphenotypes

acute respiratory distress syndrome

personalized medicine

COVID-19 patients

phenotyping

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