SCCM Resource Library-Subphenotypes of ARDS

Video Transcription

Video Summary

In this video, the speaker discusses the concept of subphenotypes in ARDS (acute respiratory distress syndrome). This is a condition that is defined by a range of symptoms and is frequently encountered in critically ill patients. However, the current classification system for ARDS is clunky and does not provide a direct link to the underlying biology or etiology of the condition. The speaker explains that phenotyping, which involves identifying subgroups within a heterogeneous population, is a pathway to precision medicine in ARDS. They describe their own research using multivariate approaches to identify two distinct phenotypes of ARDS: a hyper-inflammatory phenotype and a hypo-inflammatory phenotype. These phenotypes have different biomarker profiles and show differential responses to treatment. The speaker also discusses the challenges of implementing these phenotypes at the bedside and highlights the need for future research to validate the findings and assess the potential for phenotype-specific clinical trials.

Asset Subtitle

Pulmonary, 2023

Asset Caption

Type: one-hour concurrent | Subphenotypes in Intensive Care Medicine: Overcoming the Barrier of Heterogeneity (SessionID 1228392)

Meta Tag

Content Type Presentation

Knowledge Area Pulmonary

Membership Level Professional

Membership Level Select

Tag Acute Respiratory Distress Syndrome ARDS

Year 2023

Keywords

subphenotypes

ARDS

acute respiratory distress syndrome

phenotyping

precision medicine

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