SCCM Resource Library-Surviving Sepsis 2071

Video Transcription

Video Summary

The video transcript discusses various topics related to sepsis, including biomarkers, the microbiome, and immunomodulation. The first speaker introduces the PERSEVERE model, which predicts the risk of mortality in children with septic shock using serum protein biomarkers. The model has shown promising results in a new cohort. The second speaker emphasizes the importance of understanding the microbiome in sepsis and discusses its impact on clinical outcomes. The third speaker explores immunomodulation in sepsis and discusses various immunomodulatory therapies that have been investigated. She also discusses the role of endogenous immunomodulation and presents research on the effects of the endocannabinoid system and the pain receptor TRPV1. The video highlights the potential for precision medicine and personalized treatment approaches in sepsis. <br /><br />The article focuses on the endocannabinoid system and its role in inflammation and sepsis. It explains the different receptors of the endocannabinoid system and their activation by endocannabinoids, plant-derived cannabinoids, and synthetic cannabinoids. The article discusses the anti-inflammatory effects of N-arachidonoyl-dopamine (NADA) and THC, two endocannabinoids, in animal models. It also explores the role of the TRPV1 receptor in mediating the anti-inflammatory effects of NADA. The author suggests that studying the endocannabinoid system could lead to the development of new immunomodulatory therapies for sepsis. The article highlights the potential implications of cannabis-derived cannabinoids in managing inflammation and other processes related to sepsis. It calls for further research and understanding of the endocannabinoid system in humans.

Asset Subtitle

Sepsis, 2021

Asset Caption

The Society of Critical Care Medicine's Critical Care Congress features internationally renowned faculty and content sessions highlighting the most up-to-date, evidence-based developments in critical care medicine. This is a presentation from the 2021 Critical Care Congress held virtually from January 31-February 12, 2021.

Learning Objectives

Explore the future of biomarkers
Describe how altering microbial environments can be of therapeutic value and affect sepsis outcomes
Define predictive analytics and the future state of sepsis

Biomarkers: Beyond Procalcitonin
Hector R Wong

Gut Check: The Microbiome in Disease
Michael J. Morowitz

Immunomodulation
Judith Hellman

Predictive Analytics
Shamim Nemati

Now That We Know It, How Do We Implement It?
Christa Schorr

Meta Tag

Content Type Presentation

Knowledge Area Sepsis

Knowledge Level Foundational

Knowledge Level Intermediate

Knowledge Level Advanced

Membership Level Select

Tag Guidelines

Tag Scoring Systems

Tag Shock

Year 2021

Keywords

sepsis

biomarkers

PERSEVERE model

microbiome

immunomodulation

immunomodulatory therapies

endocannabinoid system

TRPV1 receptor

inflammation

endocannabinoids

anti-inflammatory effects

animal models

cannabis-derived cannabinoids

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