This article was first published in the Winter 2021 issue of Critical Connections. When the clock struck midnight and it officially became Thanksgiving Day, Ankit Bharat, MD, was in an operating room at Northwestern Memorial Hospital in Chicago, saving a life few people thought could be saved. The patient was Roberto Rodriguez, a 60-year-old surgical technician with COVID-19 who spent 130 days on a ventilator and extracorporeal membrane oxygenation (ECMO)—the longest reported time for a COVID-19 patient in the world. Hope for recovery was waning.  Critical Connections, the critical care industry's only newsmagazine, provides information on cutting-edge topics in critical care useful to the entire multiprofessional team.