SCCM Resource Library-The Challenges of Drug Distribution in Patients With High BMIs

The Challenges of Drug Distribution in Patients With High BMIs

Video Transcription

Video Summary

The video discusses the challenges of drug distribution in patients with high body mass index (BMI). It explains that obesity affects the absorption, distribution, metabolism, and excretion of drugs, and highlights the physiological changes in obese patients such as increased adipose tissue, lean muscle mass, blood volume, cardiac output, and renal blood flow. The video emphasizes the need for accurate weight descriptors in medication dosing and mentions that BMI is not routinely used for this purpose. It also discusses the impact of obesity on drug bioavailability, distribution, clearance, and excretion, as well as the limited literature available on drug dosing in obese patients. The video concludes by emphasizing the importance of evaluating each medication individually when considering dosing in obese patients.

Asset Subtitle

GI and Nutrition, 2023

Asset Caption

Type: two-hour concurrent | Trauma Strategies: Patients With Severe Obesity in the ICU (SessionID 1227137)

Meta Tag

Content Type Presentation

Knowledge Area GI and Nutrition

Membership Level Professional

Membership Level Select

Tag Obesity

Year 2023

Keywords

drug distribution

high body mass index

obesity

medication dosing

physiological changes

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