SCCM Resource Library-The Effect of Obesity on Pharmacotherapeutics

Video Transcription

Video Summary

Obesity can have a significant impact on the dosing of medications. There are several challenges, including a lack of guidance from industry, limited outcome studies in obese patients, and variability in pharmacokinetic data. Obesity leads to physiological changes that can affect drug distribution and clearance. It is important to use the appropriate weight metric when dosing medications, such as lean body weight or adjusted body weight, instead of total body weight. Specific medications, such as propofol, inoxaparin, vancomycin, and piperacillin/tazobactam, require careful consideration in obese patients. For example, using total body weight for propofol dosing can lead to excessive doses and increased risk of adverse cardiovascular events. Inoxaparin dosing may require higher doses in obese patients, and vancomycin dosing should consider adjusted body weight or lean body weight. Prolonged or extended infusions of medications like piperacillin/tazobactam can improve target attainment in obese patients. Overall, individualized dosing and therapeutic drug monitoring are essential in obese patients.

Asset Subtitle

GI and Nutrition, Pharmacology, 2022

Asset Caption

This session will discuss pertinent but often overlooked aspects of obesity that affect critically ill patients. Beginning with basic science implications, speakers will move through a discussion of appropriate nutrition, the physiologic affects of obesity on illness and recovery, and the implications for treatment of disease with pharmacotherapy.

Meta Tag

Content Type Presentation

Knowledge Area Pharmacology

Knowledge Area GI and Nutrition

Knowledge Level Intermediate

Knowledge Level Advanced

Membership Level Select

Tag Obesity

Tag Pharmacology

Year 2022

Keywords

Obesity

medications

dosing

pharmacokinetic data

weight metric

specific medications

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