SCCM Resource Library-The Impact of ICU Pharmacotherapy on the Skin

Video Transcription

Video Summary

In this presentation, the speaker discusses the management of acute and chronic drug-induced skin reactions, with a focus on Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis Syndrome (SJS-TEN). SJS-TEN is a severe skin reaction involving the detachment of the skin from the epidermis. It is believed to be induced by medications or drugs that activate certain immune cells, leading to cell death and necrosis. The management of SJS-TEN is largely supportive care, including surgical debridement, fluid and electrolyte management, pain control, and temperature regulation. It is important to transfer patients to specialized burn centers for optimal care. Identifying the medication that caused the reaction is also important, as stopping or tapering the medication can improve outcomes. The presentation also discusses the use of immunomodulatory therapies, such as corticosteroids, intravenous immunoglobulin (IVIG), cyclosporine, and etanercept. These therapies have shown potential benefits in inhibiting the immune response associated with SJS-TEN. However, the evidence supporting their use is limited, and more research is needed. The presentation highlights the challenges in managing SJS-TEN, including the lack of strong evidence for immunomodulatory therapies and the variability in bed surfaces and resources for preventing pressure injuries. The presenter emphasizes the importance of a multidisciplinary approach and vigilant nursing care to prevent and manage skin complications in patients with complex wounds.

Asset Subtitle

Integument, Pharmacology, 2023

Asset Caption

Type: two-hour concurrent | Skin as an Organ System: Introducing Skin Failure (SessionID 1199541)

Meta Tag

Content Type Presentation

Knowledge Area Integument

Knowledge Area Pharmacology

Membership Level Professional

Membership Level Select

Tag Integument

Tag Pharmacology

Year 2023

Keywords

Stevens-Johnson Syndrome

Toxic Epidermal Necrolysis Syndrome

supportive care

medication identification

immunomodulatory therapies

specialized burn centers

multidisciplinary approach

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