SCCM Resource Library-Thought Leader: ARDS: From Treating a Syndrome to Identifying Modifiable Traits (William C. Shoemaker Honorary Lecture)

Thought Leader: ARDS: From Treating a Syndrome to Identifying Modifiable Traits (William C. Shoemaker Honorary Lecture)

Video Transcription

Video Summary

Dr. Danny Macaulay presented the William Shoemaker Honorary Lecture, focusing on advancing the treatment of Acute Respiratory Distress Syndrome (ARDS). He highlighted ongoing efforts to transition from a broad syndromic approach to targeting specific modifiable traits, utilizing precision medicine. Dr. Macaulay detailed various sub-phenotypes within ARDS, notably the hyperinflammatory and hypoinflammatory types. Identifying these subgroups enhances the targeting of therapies, potentially improving outcomes by tailoring treatments based on phenotypic characteristics.<br /><br />He discussed significant trials revealing robust data on phenotype-induced differences in treatment responses, such as with simvastatin. The presentation also covered innovative approaches, including latent class analysis and using point-of-care devices to identify phenotypes at the bedside efficiently.<br /><br />Dr. Macaulay emphasized the necessity of developing precision medicine approaches through the PANTHER platform trial. This trial aims to evaluate therapies like simvastatin and baricitinib within identified ARDS phenotypes using a Bayesian adaptive design, enabling refined and dynamic patient care advancements. Engaging industry collaborations and embedding biobanking within trials are pivotal for sustained progress. Dr. Macaulay anticipates future trial results will further refine ARDS treatment and encourage further international collaboration in this field.

Asset Caption

Thought Leader | Thought Leader: ARDS: From Treating a Syndrome to Identifying Modifiable Traits (William C. Shoemaker Honorary Lecture)

Meta Tag

Content Type Presentation

Membership Level Professional

Membership Level Select

Year 2024

Keywords

ARDS

precision medicine

sub-phenotypes

PANTHER platform trial

latent class analysis

biobanking

Bayesian adaptive design

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