Translating Preclinical Data Into Practice: Why Therapies for Neurologic Disease Don't Work
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Video Summary
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Neuroscience, Quality and Patient Safety, 2020
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The Society of Critical Care Medicine's Critical Care Congress features internationally renowned faculty and content sessions highlighting the most up-to-date, evidence-based developments in critical care medicine. This is a presentation from the 2020 Critical Care Congress held February 16-19, 2020, in Orlando, Florida, USA.

Learning Objectives

  • Recognize pitfalls in translating data acquired in preclinical models to the clinical setting
  • Explain ways in which trial design may be responsible for failure to reproduce findings in preclinical models
  • Describe both preclinical models and the results of clinical trials to advance the field

The Models Are the Problem

Fred Rincon

The Trials Are the Problem

Joshua M. Levine

There Is No Problem; You Just Have to Understand the Challenges and How to Interpret the Data

Patrick M. Kochanek

Meta Tag
Content Type Presentation
Knowledge Area Neuroscience
Knowledge Area Quality and Patient Safety
Knowledge Level Advanced
Membership Level Select
Membership Level Professional
Membership Level Associate
Tag Stroke
Tag Evidence Based Medicine
Year 2020
Translating Preclinical Data into Practice
neurologic diseases
preclinical studies
clinical practice
models in preclinical research
internal validity of preclinical models
randomization and blinding
trial design, conduct, and analysis
preclinical testing of therapies
target engagement
personalized medicine approaches


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