SCCM Resource Library-Translation Research in Clinical Nutrition: From Bed to Bench and Back Again

Video Transcription

Video Summary

Dr. Zuden Puthacherry gave a presentation titled "Translation Research Clinical Nutrition from Bed to Bedside and Back Again" for the William Shoemaker Memorial Lecture. In the lecture, he discussed the rapid and early occurrence of muscle wasting in critically ill patients, as well as the lack of effective treatments due to a limited understanding of the underlying pathophysiology. He presented findings from his research, which showed that muscle wasting is most pronounced in patients with multi-organ failure, and that it is associated with decreased muscle protein synthesis and a net catabolic state. He also highlighted the role of bioenergetic failure and inflammation in muscle wasting. Dr. Puthacherry discussed ongoing clinical trials aimed at addressing these factors, including studies on ketogenic diets, reducing agents, and intermittent feeding. He also emphasized the importance of incorporating functional outcomes into research, as well as the need for methodological advancements in the field. Overall, his lecture provided insights into the current understanding of muscle wasting in critical illness and highlighted potential avenues for future research and interventions to prevent and treat this condition.

Asset Subtitle

GI and Nutrition, Research, 2021

Asset Caption

The Society of Critical Care Medicine's Critical Care Congress features internationally renowned faculty and content sessions highlighting the most up-to-date, evidence-based developments in critical care medicine. This is a presentation from the 2021 Critical Care Congress held virtually from January 31-February 12, 2021.

Learning Objectives

Demonstrate how interventions in clinical nutrition need to align with the altered physiology and metabolism of critically ill patients
Relate how protein and energy delivery are linked and how separating these is useful for trials but not for patients
Illustrate how nutrition and exercise are closely linked, in both health and illness, and discuss whether one should include the other

William Shoemaker Memorial Lecture

Zudin Puthucheary

Meta Tag

Content Type Presentation

Knowledge Area Research

Knowledge Area GI and Nutrition

Knowledge Level Intermediate

Knowledge Level Advanced

Membership Level Select

Tag Nutrition

Tag Clinical Research Design

Year 2021

Keywords

muscle wasting

pathophysiology

multi-organ failure

muscle protein synthesis

clinical trials

ketogenic diets

intermittent feeding

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