SCCM Resource Library-Vancomycin and Piperacillin-Tazobactam or Cefepime and Sepsis-Associated AKI Trajectory

Vancomycin and Piperacillin-Tazobactam or Cefepime and Sepsis-Associated AKI Trajectory

Video Transcription

Video Summary

The research discussed in this video focuses on the use of vancomycin and piperacillin-tazobactam (VAN-TZP) or vancomycin and CEPAPIM (VAN-FEP) in patients with sepsis-associated acute kidney injury (AKI). The study found no difference in kidney-related or clinical outcomes between the two regimens in patients with pre-existing AKI. This has potential implications for the risk-benefit discussion regarding antimicrobial selection in sepsis treatment. VAN-FEP, while an alternative, carries the risk of cefepime-induced neurotoxicity, and VAN-TZP requires the addition of metronidazole. The study suggests that the use of VAN-TZP in this patient population is safe and further research is needed to explore the use of kidney biomarkers in assessing AKI and the potential mechanisms of VAN-TZP-induced nephrotoxicity.

Asset Subtitle

Pharmacology, Sepsis, Renal, 2023

Asset Caption

Type: star research | Star Research Presentations: Pharmacology II (SessionID 30016)

Meta Tag

Content Type Presentation

Knowledge Area Pharmacology

Knowledge Area Sepsis

Knowledge Area Renal

Membership Level Professional

Membership Level Select

Tag Antibiotics

Tag Sepsis

Tag Acute Kidney Injury AKI

Year 2023

Keywords

vancomycin

piperacillin-tazobactam

CEPAPIM

sepsis-associated acute kidney injury

antimicrobial selection

	Society of Critical Care Medicine 500 Midway Drive Mount Prospect, IL 60056 USA Phone: +1 847 827-6888 Fax: +1 847 439-7226 Email: support@sccm.org	Contact Us About SCCM Newsroom Advertising & Sponsorship DONATE	MySCCM LearnICU Patients & Families Surviving Sepsis Campaign Critical Care Societies Collaborative	GET OUR NEWSLETTER
© Society of Critical Care Medicine. All rights reserved. \| Privacy Statement \| Terms & Conditions The Society of Critical Care Medicine, SCCM, and Critical Care Congress are registered trademarks of the Society of Critical Care Medicine.