SCCM Resource Library-Wake the Dying: Which Therapies Show Promise for Improving Outcomes of ICU Patients With Disorders of Consciousness?

Wake the Dying: Which Therapies Show Promise for Improving Outcomes of ICU Patients With Disorders of Consciousness?

Video Transcription

Video Summary

In this talk, the speaker discusses the clinical motivation for developing targeted therapies to promote recovery of consciousness in the intensive care unit (ICU). The aim is to accelerate the recovery of consciousness in order to decrease ventilator days and reduce the risk of complications associated with immobility. The speaker highlights the importance of early recovery of consciousness and how it can change prognosis communication to families. The current state of the science in this field is discussed, with emphasis on the lack of FDA-approved treatments or high-level randomized controlled trial evidence for their efficacy. Several therapeutic domains, including pharmacologic, electromagnetic, mechanical, sensory, and regenerative therapies, are explored as potential treatments. The speaker also discusses the targets of these therapies, such as the central thalamus and brainstem, and the safety considerations associated with these treatments. The talk concludes by highlighting the need for large-scale randomized controlled trials and the development of predictive and pharmacodynamic biomarkers for evaluating these therapies.

Asset Subtitle

Neuroscience, 2023

Asset Caption

Type: one-hour concurrent | Coma in the ICU: A Treatable Condition? (SessionID 1191496)

Meta Tag

Content Type Presentation

Knowledge Area Neuroscience

Membership Level Professional

Membership Level Select

Tag Coma

Year 2023

Keywords

recovery of consciousness

ICU

therapeutic domains

safety considerations

randomized controlled trials

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