SCCM Resource Library-What About Sepsis?

Video Transcription

Video Summary

The speaker discusses the topic of immune modulation and sepsis. They explain that sepsis is a life-threatening condition caused by a dysregulated response to infection. The objective of the talk is to explore how to measure and identify the regulated and dysregulated responses in sepsis. The speaker mentions that patients with sepsis often have excessive hyper-inflammation and impaired adaptive immunity. They discuss different approaches to manipulating the immune system, such as targeting inflammatory cytokines or vascular activation. The speaker also notes the importance of identifying the causal players in the immune response and using techniques like Mendelian randomization to understand their effects. They highlight the need for quantitative markers and thresholds that can be used at the bedside. The speaker suggests that sepsis patients are heterogeneous and that their response to treatment may vary. They give examples of how gene expression and proteomic analysis have been used to predict treatment responses. They conclude by emphasizing the need for precision medicine in sepsis treatment and the importance of combining therapies to enhance some aspects of the immune response while suppressing others.

Asset Subtitle

Sepsis, 2023

Asset Caption

Type: two-hour concurrent | Immunomodulation in Critical Illness: A 2023 Update (SessionID 1161720)

Meta Tag

Content Type Presentation

Knowledge Area Sepsis

Membership Level Professional

Membership Level Select

Tag Sepsis

Year 2023

Keywords

immune modulation

sepsis

dysregulated response

hyper-inflammation

adaptive immunity

precision medicine

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