SCCM Resource Library-What Do Steroids Do to the Critically Ill?

Video Transcription

Video Summary

In this video, the speaker discusses the use of steroids, specifically glucocorticoids, in critically ill patients. They explain that glucocorticoids are primarily used for their anti-inflammatory properties and are given to suppress the immune response, enhance cardiovascular activity, and limit pulmonary fibrosis in critically ill patients. However, glucocorticoids also have pro-inflammatory effects and can have negative effects on metabolism, skeletal muscle, and bone. The speaker then delves into the molecular biology of glucocorticoid receptors and their different isoforms, GR-alpha and GR-beta. They explain that changes in the abundance and expression of these receptors can affect the response to glucocorticoids. The speaker also discusses how certain drugs, such as antidepressants, can alter the expression of glucocorticoid receptors. The video concludes by questioning the efficacy of conducting trials with glucocorticoids when the issue may lie with glucocorticoid receptor functioning.

Asset Subtitle

Pharmacology, Pulmonary, Sepsis, 2022

Asset Caption

Corticosteroids are commonly used and frequently debated in critical illness settings. This session will review our basic understanding of the range of corticosteroid effects pertinent to critical illness and will summarize evidence for the utility of corticosteroids for two common ICU syndromes: acute respiratory distress syndrome and sepsis.

Meta Tag

Content Type Presentation

Knowledge Area Pharmacology

Knowledge Area Pulmonary

Knowledge Area Sepsis

Knowledge Level Foundational

Knowledge Level Intermediate

Knowledge Level Advanced

Learning Pathway Sepsis Resources

Membership Level Select

Tag Pharmacology

Tag Sepsis

Tag Acute Respiratory Distress Syndrome ARDS

Year 2022

Keywords

glucocorticoids

anti-inflammatory

immune response

molecular biology

glucocorticoid receptors

efficacy

Pharmacology

Pulmonary

Sepsis

Pharmacology

Sepsis

Presentation

Select

2022

Acute Respiratory Distress Syndrome ARDS

Foundational

Intermediate

Advanced

Sepsis Resources

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