SCCM Resource Library-Year in Review: Internal Medicine

Video Transcription

Video Summary

The Internal Medicine Update discussed some of the most impactful articles and studies from the past year, with a focus on sepsis, steroids, and oxygenation targets for ARDS. Dr. Kenneth Remy presented on the use of corticosteroids, thiamine, and vitamin C in sepsis, highlighting the deficiency of these vitamins in septic patients and their association with worse outcomes. He discussed various studies that have evaluated the use of vitamin C and thiamine as potential therapeutic options in sepsis, including the Hydrocortisone, Ascorbic acid, and Thiamine (HAT) therapy cocktail. While some studies showed promising results in terms of reduction in inflammatory biomarkers and mortality, others did not demonstrate a significant benefit. Dr. Paul Bergl presented on the use of steroids in ARDS, with a focus on the DEXA-ARDS study, which showed improved outcomes in patients with moderate to severe ARDS who received dexamethasone early in the disease course. He emphasized the need for further research to determine the optimal dose, duration, and patient population for steroid therapy in ARDS. Dr. Nita Khadir discussed the concept of oxygenation targets in ARDS, highlighting the need to avoid both hyperoxia and hypoxia. She presented on the LOCO2 trial, which compared conservative oxygen therapy with liberal oxygen therapy in patients with ARDS, and found a trend towards harm with conservative oxygen therapy. She also discussed the ICU-ROCKS trial, which did not find a difference in outcomes between conservative and liberal oxygen therapy. In conclusion, the Internal Medicine Update reviewed important studies and provided insights on the use of sepsis, steroids, and oxygenation targets in critically ill patients. Further research is needed to better understand these interventions and to optimize patient outcomes.

Asset Subtitle

Pharmacology, Pulmonary, 2021

Asset Caption

The Society of Critical Care Medicine's Critical Care Congress features internationally renowned faculty and content sessions highlighting the most up-to-date, evidence-based developments in critical care medicine. This is a presentation from the 2021 Critical Care Congress held virtually from January 31-February 12, 2021.

Learning Objectives

Review the most impactful studies of the past year
Discuss how these studies will impact our current understanding and best practices

Literature Review 1
Kenneth E. Remy

Literature Review 3
Paul Bergl

Literature Review 2
Nida Qadir

Meta Tag

Content Type Presentation

Knowledge Area Pharmacology

Knowledge Area Pulmonary

Knowledge Level Foundational

Knowledge Level Intermediate

Knowledge Level Advanced

Membership Level Select

Tag Analgesia and Sedation

Tag Acute Respiratory Distress Syndrome ARDS

Year 2021

Keywords

sepsis

steroids

oxygenation targets

corticosteroids

thiamine

vitamin C

ARDS

research

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