SCCM Resource Library-Year in Review: Research Section

Video Transcription

Video Summary

Dr. John Savransky, an Intensivist at Emory University Hospital, discusses the challenges of improving care for patients with a novel pathogen during a pandemic. He highlights the difficulty of determining the most effective treatments amidst the surge of information and research. He emphasizes the importance of clinical trials in guiding treatment decisions and the potential drawbacks of relying on anecdotal experience or information from publications that may later be retracted. Dr. Savransky also examines the differences between frequentist trial designs and adaptive designs. Frequentist trials are traditional randomized controlled trials, while adaptive designs allow for modifications to important trial characteristics based on information gathered during the trial. He outlines the advantages and disadvantages of each approach. While frequentist designs are widely understood and easier to implement, adaptive designs can be more efficient and patient-centric, potentially allowing more patients to receive a potentially effective treatment. Dr. Savransky concludes that both trial designs have their merits, and adaptive trials may become more common in the future. Overall, the goal is to communicate effectively and clearly to both medical professionals and the general public, in order to ensure the best possible outcomes for patients.

Asset Subtitle

Research, Quality and Patient Safety, 2022

Asset Caption

This year in review on behalf of SCCM's Research Section will focus on three timely subtopics: research design strategies during a pandemic, the role of preprint servers, and strategies for interacting with the media.

Learning Objectives:
-Review arguments in favor of Bayesian platform strategies versus traditional frequentist trials and the successes and failures of each during the pandemic
-Discuss the benefits and drawbacks of preprints (full research manuscripts that have not yet undergone peer review)
-Address a strategic approach to engaging the media and how to message effectively without being misquoted

Meta Tag

Content Type Presentation

Knowledge Area Research

Knowledge Area Quality and Patient Safety

Knowledge Level Foundational

Knowledge Level Intermediate

Knowledge Level Advanced

Membership Level Select

Tag Clinical Research Design

Tag Evidence Based Medicine

Tag Communication

Year 2022

Keywords

Dr. John Savransky

Intensivist

clinical trials

treatments

adaptive designs

randomized controlled trials

patient-centric

efficiency

best possible outcomes

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