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Guidelines-Directed Care of HRS/AKI in the ICU: Evidence-Based Management and Monitoring of Multiorgan Failure in ACLF Patients
Continuing Education

Accredited continuing education (ACE) release date: January 22, 2023 
SCCM Product Code: SWEB23B
ACE expiration date: May 1, 2024 
Estimated time for activity completion: 1 hour 

Software/Hardware and Internet Requirements
Learning Objectives
  • Discuss current guidelines for the effective management of multiorgan failure arising from ACLF
  • Describe the extrahepatic consequences of ACLF
  • Explain evidence-based volume management protocols in AKI patients that establish a diagnosis of HRS/AKI, while mitigating risks from fluid overload
  • Apply guideline-recommended vasoconstrictor therapy for patients who meet diagnostic criteria for HRS/AKI
  • Explain how to monitor patients with ACLF and HRS/AKI for treatment-emergent adverse events that may worsen prognosis
Target Audience

The target audience comprises physicians, pharmacists, nurses, and other HCPs who care for critically ill patients with multiorgan failure in acute on chronic liver failure.

Type of Activity

This is an online activity that will allow learners to improve the knowledge and competence of HCPs managing patients with ACLF, decompensated cirrhosis and multiorgan failure.


The Society of Critical Care Medicine (SCCM) supports recommendations that will promote lifelong learning through continuing education. SCCM promotes activities that encourage the highest quality in education that will enhance knowledge, competence, or performance in critical care practice. This activity will meet the following competencies: 

  • Medical knowledge
  • Practice-based improvement and improvement
Claiming Credit

You can access the course materials; complete your evaluation; and claim your ACE credit by logging in to your MySCCM account with your SCCM Customer ID and password, then clicking on the icon for the course you are enrolled in under the MyLearning tab. If needed, you can click "Forgot my password" to reset your secure password.

Credit Hours


Accreditation Statement: The Society of Critical Care Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. 

Designation Statement: The Society of Critical Care Medicine designates this enduring educational activity for a maximum of 1.0 AMA PRA Category 1 credits™. Physicians should claim only those hours of credit that they actually spent in the educational activity.

The ACCME crdits that physicians earn from this activity will be submitted to ACCME’s CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported ACCME credit. Visit to create your account.

Nurses: The Guidelines – Directed Care of HRS/AKI in the ICU activity has been approved by the California Board of Registered Nursing, Provider No. 8181, for up to 1.0 contact hours.


The Society of Critical Care Medicine is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education. This enduring educational activity provides up to 1.0 contact hours of continuing education credit.  (0236-9999-23-027-H01-P) 

SCCM reports to a continuing pharmacy education (CPE) tracking service, CPE Monitor, which will authenticate and store data for completed CPE units received by pharmacists and pharmacy technicians. The tracking system will make CPE data for each participant available to the state boards of pharmacy where the participant is licensed or registered. After CPE units are processed by the Accreditation Council for Pharmacy Education (ACPE) and the National Association of Boards of Pharmacy (NABP), pharmacists and pharmacy technicians will be able to log in to a comprehensive electronic profile to access information about their completed CPE. 

Physician Assistants: The American Academy of Physicians Assistants (AAPA) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by Accreditation Council for Continuing Medical Education (ACCME) or a recognized state medical society. Physician assistants may receive a maximum of 1.0 Category 1 credits for completing this activity. 

This educational activity was funded in part by an educational grant from Mallinckrodt.

SCCM Grievance Procedures Policy

To provide due process in the evaluation and mediation of grievances concerning ACE activities, this Grievance Procedures Policy was developed. Grievances may concern, but are not limited to, the awarding of credit for individual participation and/or registration fees issues.

  • A written complaint or grievance should be submitted to the Education Department.
  • The Education Department will attempt to resolve the grievance of the complainant.
  • If the initial response is unsatisfactory to the complainant, the matter will be referred to the CEO/EVP for action.
  • If the response from the CEO/EVP is unsatisfactory to the complainant, the matter will be referred to the SCCM Executive Committee. The ruling of the Executive Committee will be final.
The content of this activity has been peer reviewed and has been approved for compliance. The faculty and contributors have indicated the following financial relationships, which have been resolved through an established conflict-of-interest resolution process and have stated that these reported relationships will not have any impact on their ability to provide unbiased content.

Amy L. Dzierba, PharmD, BCCCP
Critical Care Pharmacist
New York-Presbyterian Hospital
New York, New York, USA
No relevant financial relationship(s) to disclose

Laura E. Evans, MD, MS, MSc, FCCM
Medical Director of Critical Care
University of Washington Medical Center
Seattle, Washington, USA
Scientific Advisory Board – Endpoint Health

Ashish K. Khanna, MD, FCCP, FASA, FCCM
Anesthesiologist & Intensivist, Associate Professor of Anesthesiology
Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, USA
Advisor – Retia Medical; Consultant – Edward Life Sciences, GE Healthcare, Medtronic, Philips North America, Potrero Medical; Researcher – Caretaker Medical, Edwards Life Sciences, Potrero Medical, Retia Medical

Constantine J. Karvellas, MD, MS, FRCPC, FCCM
University of Alberta
Edmonton, Alberta, Canada
No relevant financial relationship(s) to disclose

Jody C. Olson, MD, FACP
Senior Associate Consultant
Mayo Clinic Rochester
Rochester, Minnesota, USA
Advisory Board - Mallinckrodt; Consultant – Mallinckrodt; Scientific Advisory Board – Mallinckrodt

Ram Subramanian, MD, MBA, FCCM
Professor of Medicine and Surgery
Emory University
Atlanta, Georgia, USA Consultant - Mallinckrodt
Availability: On-Demand
Expires on May 01, 2024
Credit Offered:
1 AMA PRA Category 1 Credit Credit
1 ACPE (Pharmacy) – Home Study Credit
1 CABN (Nursing) Credit
1 Certificate of Participation Credit
1 AAPA Credit


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