• Develop next steps in clinical application of current research in pathogen-targeted therapies (toxin-directed or vaccines) and utilization of immune targeting agents (IL-7, GM-CSF, or anti-heme)
• Examine current strategies and next-generation targeted therapies to patient immune phenotype in sepsis
• Recognize the current state of the science and future directions in the relevance of sepsis immune phenotype and potential diagnostic modalities including monocyte phenotyping with HLA-DR expression and IFN-G production with flow cytometry and ELISPOT
• Discuss future directions for current research in immunoadjuvant therapies (checkpoint inhibitors, IL-7, IL-8, IL-10), Pathogen-specific therapies (vaccines, antimicrobials), and immune dysregulation modifying agents as therapeutic targets (anti-heme, anti-hb)

• Advanced practice nurses
• Anesthesiologists
• Clinical nurse specialists
• Critical care educators
• In-training professionals
• Nurses, adult and pediatric
• Pharmacists
• Physicians
• Physician assistants
• Research scientists
• Other critical care practitioners

This enduring activity includes elements that increase knowledge, application, and practice for the multiprofessional team members.

• Quality improvement and patient safety
• Patient- and family-centered care
• Clinical knowledge
• Communication
• Multiprofessionalism and teamwork
• Translation of research from bench to bedside

You can access the pretest, course materials, and posttest; complete your evaluation; and claim your ACE credit by logging in to your MySCCM account with your SCCM Customer ID and password, then clicking on the icon for the course you are enrolled in under the MyLearning tab. If needed, you can click "Forgot my password" to reset your secure password.  

Physicians:
Accreditation Statement: The Society of Critical Care Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Designation Statement: The Society of Critical Care Medicine designates this enduring educational activity for a maximum of 3.75 AMA PRA Category 1 credits™. Physicians should claim only those hours of credit that they actually spent in the educational activity.

The ACCME credits that physicians earn from this activity will be submitted to ACCME’s CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported ACCME credit. Visit www.cmepassport.org to create your account.

Nurses:
The Deep Dive: The Final Frontier of Sepsis Precision Medicine Online activity has been approved by the California Board of Registered Nursing, Provider No. 8181, for up to 3.75 contact hours.

Pharmacists:
The Society of Critical Care Medicine is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education. This enduring educational activity provides up to 3.75 contact hours of continuing education credit.
(0236-0000-24-143-H01-P)

SCCM reports to a continuing pharmacy education (CPE) tracking service, CPE Monitor, which will authenticate and store data for completed CPE units received by pharmacists and pharmacy technicians. The tracking system will make CPE data for each participant available to the state boards of pharmacy where the participant is licensed or registered. After CPE units are processed by the Accreditation Council for Pharmacy Education (ACPE) and the National Association of Boards of Pharmacy (NABP), pharmacists and pharmacy technicians will be able to log in to a comprehensive electronic profile to access information about their completed CPE.

Physician Assistants:
The American Academy of Physicians Assistants (AAPA) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by Accreditation Council for Continuing Medical Education (ACCME) or a recognized state medical society. Physician assistants may receive a maximum of 3.75 Category 1 credits for completing this activity.

Successful completion of this accredited continuing education (ACE) activity, which includes participation and a passing score of 70% in the evaluation component/posttest, enables the participant to earn up to 3.75 medical knowledge maintenance of certification (MOC) points in the American Board of Internal Medicine (ABIM), American Board of Anesthesia (ABA), American Board of Surgery (ABS), American Board of Pediatrics (ABP), and American Board of Thoracic Surgery (ABTS) MOC programs. Participants will earn MOC points equivalent to the amount of ACE credits claimed for the activity.

This course meets the requirements for MOC for up to 3.75 credits.

The MOC credits that physicians earn from this activity will be submitted to ACCME’s CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported ACCME credit. Visit www.cmepassport.org to create your account.

• A written complaint or grievance should be submitted to the Education Department.
• The Education Department will attempt to resolve the grievance of the complainant.
• If the initial response is unsatisfactory to the complainant, the matter will be referred to the CEO/EVP for action.
• If the response from the CEO/EVP is unsatisfactory to the complainant, the matter will be referred to the SCCM Executive Committee. The ruling of the Executive Committee will be final.

The content of this activity has been peer reviewed and has been approved for compliance. The faculty and contributors have indicated the following financial relationships, which have been mitigated through an established conflict-of-interest resolution process and have stated that these reported relationships will not have any impact on their ability to provide unbiased content.

Planners:
Marilyn N. Bulloch, PharmD, BCPS, SPP, FCCM
Associate Clinical Professor and Director of Strategic Operations
Auburn University Harrison School of Pharmacy
Tuscaloosa, Alabama, USA
Advisory Board – Shionogi (terminated)

Roshni Sreedharan, MD, FASA, FCCM
Anesthesiologist Cleveland Clinic Foundation
Cleveland, Ohio, USA
No relevant financial relationship(s) to disclose

Tamas Szakmany, MD, PhD, FCCM
Consultant in Intensive Care
Aneurin Bevan University Health Board
Newport, United Kingdom
Board Member – ICNARC; Speaker – ThermoFisher Ltd; Advisory Board – Paion UK, LTD (terminated)

Kenneth Remy, MD, MSc, MSCI, FCCM
Associate Professor
Case Western Reserve University/University Hospitals Cleveland Medical Center
Cleveland, Ohio, USA
Disclosure(s): Immune Functional Diagnostics: Owner/Co-Owner Founder/Co-Founder (Ongoing)

Faculty:
Juliane Bubeck-Wardenburg, MD, PhD
Professor
Washington University in St. Louis
St. Louis, Missouri, USA
Disclosure(s): Aridis Pharmaceuticals: Holder of Intellectual Property Rights (Ongoing); Forward Defense LLC: Holder of Intellectual Property Rights (Ongoing), Major Stockholder (not including mutual funds) (Ongoing), Owner/Co-Owner Founder/Co-Founder (Ongoing)

Kenneth Remy, MD, MSc, MSCI, FCCM
Associate Professor
Case Western Reserve University/University Hospitals Cleveland Medical Center
Cleveland, Ohio, USA
Disclosure(s): Immune Functional Diagnostics: Owner/Co-Owner Founder/Co-Founder (Ongoing)

James T. Ross, MD
Assistant Professor of Surgery
Case Western Reserve University/University Hospitals Cleveland Medical Center
Cleveland, Ohio, USA
No relevant financial relationship(s) to disclose

Jamie L. Sturgill, PhD
Assistant Professor
University of Kentucky
Lexington, Kentucky, USA
No relevant financial relationship(s) to disclose