Deep Dive: Post-Cardiac Arrest Online-Tip of the Iceberg: Pharmacotherapy for the Post-Arrest Patient

Video Transcription

Video Summary

In this video, Brooke Barlow, a critical care pharmacist, discusses the pharmacotherapy considerations for post-cardiac arrest patients undergoing targeted temperature management (TTM). She highlights the importance of preventing recurrent arrest and identifying the underlying cause of the arrest for targeted management. She also emphasizes the need to prevent secondary brain injury and discusses the critical care management during the first 72 hours, including control of fevers, hemodynamic support, and other supportive care measures.<br />Barlow also discusses the pharmacokinetic alterations that occur during TTM, such as changes in drug absorption, distribution, metabolism, and elimination. She advises the use of intravenous drug routes, consideration of altered protein binding, and the potential for renal injury affecting drug clearance.<br />Additionally, Barlow addresses complications that can occur in post-cardiac arrest patients, including hemodynamic complications, cardiovascular effects during TTM, shivering, seizures, bleeding risks, electrolyte imbalances, blood glucose management, and infectious complications. She provides an overview of pharmacotherapeutic options for managing these complications.<br />Barlow concludes by highlighting ongoing clinical trials in pharmacotherapy for post-cardiac arrest patients and emphasizes the importance of staying informed about new research developments in this area.

Keywords

pharmacotherapy considerations

post-cardiac arrest patients

targeted temperature management

critical care management

pharmacokinetic alterations

complications in post-cardiac arrest patients

clinical trials

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